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Sometimes a developer will need to make a transparent GIF, such as for a web page. This should be trivial - you essentially want to say "make every pixel that is color X be transparent", but most standard development tools (VS, Paint, etc...) don't let you do this. While there are lots of expensive graphics programs out there, most developers don't have these.
An easy way to make a transparent gif is using the free Paint.Net (written entirely in .Net).
I find this convenient for simple web imaging needs. Also, Paint.Net has a ton of other features, like gradients, blends, and special effects.

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Isn't there a step 6? I've got all the pixels selected, but then what?
Oops, yes. Step 6: Once the region is selected, then hit the delete key.
Thanks! I have to make temporary icons and toolbar buttons (which are
subsequently replaced by our marketing team with professional ones) and I
hate using Windows Paint precisely because I can't make the "background"
transparent. I'll never be without Paint.NET from now on :)